circRNA basic information
circBase ID: -
Name: hsa_circ_HMGCS1
Synonym: hsa_circRNA_103829
Host Gene: HMGCS1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 -
MONDO name: -
Disease details: aging
Disease DO ID:
 -
Disease MeSH ID:
 D000375
Disease NCIt ID:
 C16269
Disease ICD11 ID:
 -
Disease OMIM ID:
 502000
Species: Human
Species details: Homo sapiens
Tissue specimen:

granulosa cells (GCs)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-625-3p, hsa-miR-129-5p
Biological function: Associated with maternal aging in granulosa cells; influenced by gonadotropin dose.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circRNA_103829 (hsa_circRNA_103829) is up-regulated in granulosa cells from advanced-age women compared with young women, and its level is also higher in women receiving high doses of gonadotropins. No downstream mechanism or clinical prediction model was established for this circRNA in the study.
Confidence score:

0.4032
Other information
Title:

Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.

Journal: PloS one
Published: 2017
PubMed ID: 28644873
Study type:

combined biological and clinical study
Data availability: GSE97193
Code availability: -