| Expression pattern: |
DN |
| Associated gene: |
mRNAs in ceRNA network |
| Associated microRNA: |
- |
| Biological function: |
Identified as a diagnostic biomarker in NSCLC; functional analysis associated the five circRNA biomarkers with tumor progression and miRNA regulation, but no individual functional experiment was performed for this circRNA. |
| Molecular mechanism: |
Bioinformatically constructed ceRNA network; experimental validation of the regulatory mechanism was not performed. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Potential diagnostic biomarker for NSCLC with AUC > 0.85; included in a nomogram model for patients with NSCLC. |
| Description: |
hsa_circ_0015278 was significantly downregulated in NSCLC tumor tissues and was identified as one of five potential diagnostic circRNA biomarkers. The paper linked the five biomarkers to predicted ceRNA regulation and tumor-related pathways, but did not experimentally validate a specific mechanism for this circRNA. |
| Confidence score: |
0.459 |