circRNA basic information
circBase ID: hsa_circ_0001098
Name: -
Synonym: hsa_-circ_0001098
Host Gene: -
Genomic location(hg19): chr2:215632205-215646233:-
Genomic location(hg38): chr2:214767481-214781509:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatitis B virus-induced hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HBV-related HCC tissues; adjacent non-tumor tissues
Cell lines:

HepG2; HepAD38
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IGF2BP1, AGO2
Associated microRNA: miR-2110
Biological function: Promotes HCC progression and promotes cell proliferation.
Molecular mechanism: ceRNA mechanism: HBV-upregulated hsa_circ_0001098 sponges miR-2110 to modulate IGF2BP1 expression.
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Colony Formation Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

Potential therapeutic target for HBV-induced HCC.
Description:

hsa_circ_0001098 is up-regulated in HBV-positive HepAD38 cells and HBV-related HCC tissues. It promotes HCC cell proliferation and progression through a ceRNA mechanism in which hsa_circ_0001098 sponges miR-2110 to increase IGF2BP1 expression.
Confidence score:

0.7165
Other information
Title:

Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.

Journal: Microbial pathogenesis
Published: 2025
PubMed ID: 39710348
Study type:

combined bioinformatics, biological and clinical study
Data availability: Data will be made available on request; Supplementary data to this article can be found online at https://doi.org/10.1016/j.micpath.2024.107248
Code availability: -