| Expression pattern: |
UP |
| Associated gene: |
MTA2 |
| Associated microRNA: |
miR-1236-3p |
| Biological function: |
promotes proliferation, migration and invasion of gastric cancer cells; promotes xenograft tumour growth |
| Molecular mechanism: |
acts as a miRNA sponge for miR-1236-3p to regulate MTA2 expression (ceRNA mechanism) |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circMAN1A2 was overexpressed in GC tissues and in the preoperative plasma of GC patients, suggesting potential diagnostic value; higher expression associated with advanced stage |
| Description: |
circMAN1A2 is induced/upregulated by H. pylori in gastric cancer cells and tissues, promotes malignant phenotypes (proliferation, migration, invasion) and enhances xenograft growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1236-3p to increase MTA2 expression, and it may serve as a diagnostic biomarker due to elevated levels in patient plasma. |
| Confidence score: |
0.7519 |