| Expression pattern: |
UP |
| Associated gene: |
ATG2B, RNF5, SIRT1 |
| Associated microRNA: |
- |
| Biological function: |
Promotes autophagy, proliferation, invasion, and migration; inhibits apoptosis; promotes tumor growth in vivo. |
| Molecular mechanism: |
circDHX8 competitively binds RNF5 to inhibit RNF5-mediated ubiquitination and degradation of ATG2B, increasing ATG2B protein stability and promoting autophagy-driven malignant progression. |
| Biological pathway or process: |
autophagy (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ubiquitination (inhibits) |
| Detected method: |
Q
S
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; TUNEL; Western Blot; IF (Immunofluorescence); RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Bioinformatics Analysis; In Vivo Animal Model; Microarray |
| Clinical significance: |
Higher circDHX8 expression is associated with advanced gastric cancer and worse prognosis; circDHX8 and ATG2B may predict GC prognosis. |
| Description: |
circDHX8 (hsa_circ_0003899) is up-regulated in gastric cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. Mechanistically, it binds RNF5 to block RNF5-mediated ubiquitination/degradation of ATG2B, stabilizing ATG2B and enhancing autophagy. High circDHX8 expression correlates with advanced disease and poor prognosis. |
| Confidence score: |
0.8491 |