| Expression pattern: |
UP |
| Associated gene: |
SLC19A1, CSF1, RAB3IL1, TGM2, GPR68, BIBD11, SIPR4, TGFB1I1, NUDT8, GPT2, NPTX2 |
| Associated microRNA: |
miR-5008-5p |
| Biological function: |
Potential diagnostic biomarker for prostate cancer; positively correlated with age, PSA level, Gleason score, and aggressive prostate cancer; may affect prostate cancer progression through SLC19A1-related folate regulation. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving circ_0062019-miR-5008-5p-SLC19A1; possible regulation of folate level through SLC19A1. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
AUC of circ_0062019 was 0.828; combined detection with circ_0057558 and PSA improved diagnostic performance for distinguishing PCa from BPH; circ_0062019 was positively correlated with PSA level, Gleason score, and aggressive cancer. |
| Description: |
circ_0062019 was up-regulated in prostate cancer cell lines and tissues and was validated by qRT-PCR. The study proposes circ_0062019 as a diagnostic biomarker and suggests a predicted circ_0062019/miR-5008-5p/SLC19A1 axis that may influence prostate cancer progression through folate-related biology. |
| Confidence score: |
0.5047 |