circRNA basic information
circBase ID: hsa_circ_0008234
Name: hsa_circ_FOXP1
Synonym: circFOXP1
Host Gene: FOXP1
Genomic location(hg19): chr3:71090478-71102924:-
Genomic location(hg38): chr3:71041327-71053773:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimens; HCC tumors
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Up-regulated in HCC tumors with CTNNB1 mutations; the current study validated expression but did not experimentally test circFOXP1 function.
Molecular mechanism: not specified in this study
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0008234, also referred to as circFOXP1, was validated by qPCR as up-regulated in HCC tumors with CTNNB1 mutations. This paper did not directly test its functional mechanism in the CTNNB1-mutant HCC context.
Confidence score:

0.5129
Other information
Title:

Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Published: 2025
PubMed ID: 38918127
Study type:

combined biological and clinical study
Data availability: Data will be made available on request; Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.dld.2024.06.001
Code availability: -