| Expression pattern: |
UP |
| Associated gene: |
XIAP |
| Associated microRNA: |
miR-153-5p, miR-183-5p |
| Biological function: |
CircPAN3 promotes ADM resistance in AML cells; down-regulation of circPAN3 increases sensitivity of THP-1/ADM cells to ADM and increases apoptotic caspase activation markers. |
| Molecular mechanism: |
CircPAN3 acts through a circPAN3-miR-153-5p/miR-183-5p-XIAP axis, likely functioning as a miRNA sponge to regulate XIAP protein expression post-transcriptionally and thereby mediate ADM resistance. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Western Blot; Luciferase Reporter Assay |
| Clinical significance: |
CircPAN3 may be a valuable indicator for predicting clinical efficacy of chemotherapy in AML patients and a potential target for reversing drug resistance in AML. |
| Description: |
CircPAN3 is up-regulated in ADM-resistant AML cells and in bone marrow samples from refractory/recurrent AML patients. It promotes drug resistance by modulating the miR-153-5p/miR-183-5p-XIAP axis, increasing XIAP protein expression and suppressing apoptotic caspase activation. The study suggests circPAN3 may help predict chemotherapy efficacy and may be a therapeutic target for reversing AML drug resistance. |
| Confidence score: |
0.6676 |