circRNA basic information
circBase ID: hsa_circ_0002360
Name: hsa_circ_RUNX1
Synonym: hsa_circRNA_103123
Host Gene: RUNX1
Genomic location(hg19): chr21:36206706-36231875:-
Genomic location(hg38): chr21:34834409-34859578:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LUAD tissues; para-cancerous tissues; normal lung tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: ADCY9, NMUR1
Associated microRNA: hsa-miR-1293
Biological function: May be involved in pathogenesis and prognosis in patients with LUAD.
Molecular mechanism: ceRNA mechanism via hsa-miR-1293 to regulate ADCY9 and NMUR1 (predicted regulatory network).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

May have clinical application value as prognostic markers or novel biomarkers in LUAD.
Description:

This study computationally identified hsa_circ_0002360 as down-regulated in LUAD microarray datasets and incorporated it into a predicted ceRNA network. The proposed axis is hsa_circ_0002360-hsa-miR-1293-(ADCY9, NMUR1), potentially related to LUAD pathogenesis and prognosis.
Confidence score:

0.1768
Other information
Title:

Identification of the circRNA-miRNA-mRNA Prognostic Regulatory Network in Lung Adenocarcinoma.

Journal: Genes
Published: 2022
PubMed ID: 35627270
Study type:

bioinformatics study
Data availability: GSE101684; GSE101586; GSE112214; GSE158695; TCGA
Code availability: -