| Expression pattern: |
UP |
| Associated gene: |
RAB8A |
| Associated microRNA: |
miR-613 |
| Biological function: |
Aggravates cervical cancer cell growth (proliferation) and metastasis-related behaviors (migration and invasion). |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-613, thereby modulating the miR-613 target RAB8A (circ_0001823/miR-613/RAB8A axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Clinical Sample Validation |
| Clinical significance: |
Potential therapeutic target for cervical cancer. |
| Description: |
circ_0001823 is up-regulated in cervical cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-613 to relieve repression of RAB8A, forming a circ_0001823/miR-613/RAB8A regulatory axis. |
| Confidence score: |
0.7911 |