circRNA basic information
circBase ID: hsa_circ_0067934
Name: -
Synonym: circ_0067934
Host Gene: -
Genomic location(hg19): chr3:170013698-170015181:+
Genomic location(hg38): chr3:170295910-170297393:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; matched normal tissues; adjacent normal tissues; tumor tissues
Cell lines:

SiHa; CaSki; Hela; C4-1; NC104
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: EIF3C
Associated microRNA: miR-545
Biological function: Promotes cervical cancer cell proliferation, colony formation, migration, invasion, EMT, and tumor growth in vivo; acts as an oncogenic factor in cervical cancer progression.
Molecular mechanism: circ_0067934 functions through a ceRNA-like mechanism by interacting with miR-545, inhibiting miR-545, and upregulating EIF3C expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis
Clinical significance:

circ_0067934 upregulation was associated with advanced stage, lymph node metastasis, and poor prognosis in cervical cancer patients; high circ_0067934 expression predicted low survival rate.
Description:

circ_0067934 is upregulated in cervical cancer tissues and cell lines and its high expression is associated with advanced FIGO stage, lymph node metastasis, and poor survival. Functionally, circ_0067934 promotes proliferation, colony formation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it facilitates cervical cancer progression through the miR-545/EIF3C axis.
Confidence score:

0.7548
Other information
Title:

Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis.

Journal: Journal of cellular physiology
Published: 2019
PubMed ID: 30362562
Study type:

combined biological and clinical study
Data availability: -
Code availability: -