| Expression pattern: |
UP |
| Associated gene: |
CX3CR1 |
| Associated microRNA: |
miR-550a-3p |
| Biological function: |
circPVT1 promotes OA progression by inhibiting chondrocyte proliferation, increasing apoptosis, promoting inflammatory mediator release, and accelerating extracellular matrix degradation. |
| Molecular mechanism: |
circPVT1 acts as a ceRNA that competes with miR-550a-3p, reduces miR-550a-3p-mediated suppression of CX3CR1, and indirectly increases CX3CR1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); apoptosis (promotes); inflammation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; ELISA |
| Clinical significance: |
Elevated circPVT1 expression is associated with poor prognosis in osteoarthritis patients and circPVT1 may serve as a diagnostic biomarker and therapeutic target. |
| Description: |
circPVT1 is upregulated in OA chondrocytes and promotes osteoarthritis progression. Mechanistically, it functions as a ceRNA for miR-550a-3p, thereby relieving repression of CX3CR1 and increasing CX3CR1 expression. Functionally, elevated circPVT1 suppresses chondrocyte proliferation, promotes apoptosis and inflammatory cytokine production, and accelerates extracellular matrix degradation, suggesting biomarker and therapeutic-target potential. |
| Confidence score: |
0.6521 |