circRNA basic information
circBase ID: -
Name: hsa_circ_PTK2
Synonym: circ-PTK2
Host Gene: PTK2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow; bone marrow mononuclear cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Differentially expressed in AML; it did not differentiate AML patients from healthy donor controls by ROC analysis.
Molecular mechanism: Not experimentally specified for this circRNA.
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

circ-PTK2 was up-regulated in AML but did not differentiate AML patients from healthy donor controls and was not correlated with risk stratification, complete remission, EFS or OS.
Description:

circ-PTK2 was validated by RT-qPCR as up-regulated in AML BMMCs. Unlike several other validated candidates, it did not significantly distinguish AML patients from healthy controls in ROC analysis and had no reported survival association.
Confidence score:

0.636
Other information
Title:

Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.

Journal: American journal of translational research
Published: 2020
PubMed ID: 32509169
Study type:

combined clinical and bioinformatics study
Data availability: -
Code availability: -