circRNA basic information
circBase ID: -
Name: hsa_circ_USP36
Synonym: circUSP36
Host Gene: USP36
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HeLa; SiHa; Ect1/E6E7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: FBXO5
Associated microRNA: miR-520d-5p
Biological function: promotes cervical cancer cell proliferation, invasion, and migration; reduces apoptosis
Molecular mechanism: circUSP36 competitively binds miR-520d-5p and positively regulates FBXO5 expression
Biological pathway or process:

proliferation (promotes); invasion (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

CircUSP36 is up-regulated in cervical cancer cell lines and acts as an oncogenic circRNA. It promotes proliferation, invasion, and migration and suppresses apoptosis by competitively binding miR-520d-5p, thereby increasing FBXO5 expression.
Confidence score:

0.5627
Other information
Title:

CircUSP36 promotes FBXO5 expression to accelerate cervical cancer progression by targeting miR-520d-5p.

Journal: Cytotechnology
Published: 2025
PubMed ID: 41250776
Study type:

biological research
Data availability: The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -