circRNA basic information
circBase ID: -
Name: hsa_circ_KIAA1191
Synonym: circRNA4806
Host Gene: KIAA1191
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

HPV negative normal cervical epithelium; HPV16 positive normal cervical epithelium; HPV16 positive high-grade squamous intraepithelial lesion; HPV16 positive cervical squamous epithelial cell carcinoma tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: NOP56, ELAVL1, NUMA1, SF3B4, FAM120A, CELF2, PRPF8, UPF1, TNRC6A, FMR1, NUDT21, AGO2, TROVE2, FUS, DGCR8, SRSF7, SRSF1, NOP58, U2AF1, U2AF2, SRSF9, HNRNPU, DDX54, HNRNPA2B1, SF3A3, RBM22, PTBP1, HNRNPC, TRA2A, HNRNPM, ZNF184, ZC3H7B, SMNDC1, AUH, MSI1, HNRNPA1, LIN28B, RANGAP1, BCCIP, IGF2BP1, GTF2F1, IGF2BP3, IGF2BP2, HNRNPUL1, TAF15, BUD13, RBFOX2, FBL, EIF4A3, AIFM1, RNF219, SAFB2, CSTF2T, RBM47, SLTM, EIF4G2, DDX42
Associated microRNA: hsa-miR-31-5p
Biological function: Potential competing endogenous RNA involved in cervical cancer progression through miRNA sponging and predicted cancer-associated pathways.
Molecular mechanism: Predicted ceRNA mechanism via hsa-miR-31-5p; predicted RBP interactions.
Biological pathway or process:

ceRNA regulation (other); lipid metabolism (other); other pathway/process (other)
Detected method:
S
Validation methods:

Bioinformatics Analysis; RNA-seq
Clinical significance:

Potential biomarker and therapeutic target for cervical cancer progression.
Description:

circRNA4806/hsa-KIAA1191_0001 was identified as a down-regulated DE circRNA during cervical cancer progression. It was predicted to function as a ceRNA for hsa-miR-31-5p and to interact with multiple RBPs, but it was not experimentally validated by qRT-PCR in this study.
Confidence score:

0.1768
Other information
Title:

Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.

Journal: Journal of applied genetics
Published: 2025
PubMed ID: 40531429
Study type:

bioinformatics study
Data availability: GSE147009; TCGA; CircAtlas; Transcirc; MiRWalk 3.0; CMAP2; CTDBASE
Code availability: -