| Expression pattern: |
DN |
| Associated gene: |
p21 |
| Associated microRNA: |
miR-9 / hsa-miR-9-5p |
| Biological function: |
Suppresses HCC progression, inhibits HCC cell proliferation and invasion, enhances apoptosis, and suppresses tumor growth in vivo. |
| Molecular mechanism: |
circMTO1 acts as a miR-9 sponge to eliminate the oncogenic effect of miR-9 and upregulate p21 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
Microarray; RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; circRIP; FISH / smFISH; Transfection; EdU Staining; Transwell Assay; Western Blot; IHC (Immunohistochemistry); ELISA; In Vivo Animal Model; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Decreased circMTO1 expression is correlated with poor prognosis of HCC patients, and circMTO1 may serve as a prognosis predictor and therapeutic target. |
| Description: |
circMTO1 is significantly downregulated in human HCC tissues, and reduced expression is associated with poor patient prognosis. Functionally, circMTO1 acts as a tumor suppressor by sponging oncogenic miR-9, thereby promoting p21 expression and inhibiting HCC proliferation, invasion, and in vivo tumor growth while enhancing apoptosis. |
| Confidence score: |
0.7875 |