circRNA basic information
circBase ID: hsa_circ_0001846
Name: hsa_circ_UBAP2
Synonym: circ-UBAP2
Host Gene: UBAP2
Genomic location(hg19): chr9:33944362-33956144:-
Genomic location(hg38): chr9:33944364-33956146:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

TNBC tissues; normal tissues; tumour tissue samples; lung
Cell lines:

MCF-10A; T47D; BT-20; SK-BR-3; MCF-7; MDA-MB-468; MDA-MB-231
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MTA1
Associated microRNA: miR-661
Biological function: Promotes TNBC cell proliferation, migration, tumour growth and metastasis, and inhibits apoptosis.
Molecular mechanism: circ-UBAP2 acts as a cytoplasmic ceRNA that sponges miR-661 to increase MTA1 expression, thereby promoting TNBC progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Bioinformatics Analysis; circRIP; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Survival Analysis; Cohort Study
Clinical significance:

High circ-UBAP2 expression was associated with larger tumour size, advanced TNM stage, lymph node metastasis and unfavourable prognosis; circ-UBAP2 may serve as a prognostic biomarker and therapeutic target for TNBC.
Description:

circ-UBAP2 is upregulated in TNBC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ-UBAP2 promotes TNBC proliferation, migration, tumour growth and metastasis while suppressing apoptosis. Mechanistically, it mainly localizes in the cytoplasm and acts through the miR-661/MTA1 ceRNA axis.
Confidence score:

0.8192
Other information
Title:

Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway.

Journal: Biochemical and biophysical research communications
Published: 2018
PubMed ID: 30314706
Study type:

combined biological and clinical study
Data availability: GSE101123; https://doi.org/10.1016/j.bbrc.2018.10.026; https://circinteractome.nia.nih.gov/; http://kmplot.com/analysis/
Code availability: -