circRNA basic information
circBase ID: hsa_circ_0037096
Name: hsa_circ_PCSK6
Synonym: -
Host Gene: PCSK6
Genomic location(hg19): chr15:101906400-101910728:-
Genomic location(hg38): chr15:101366195-101370523:-
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted miRNA response elements via computational analysis (TargetScan/miRanda).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for pancreatic cancer diagnosis (EV circRNA in plasma).
Description:

hsa_circ_0037096 is up-regulated in PDAC patient plasma EVs and is among the top circRNAs validated by RT-qPCR to match circRNA-seq. Functional mechanisms are limited to predicted circRNA-miRNA interactions.
Confidence score:

0.5466
Other information
Title:

Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.

Journal: FEBS open bio
Published: 2019
PubMed ID: 31605569
Study type:

combined biological and clinical study
Data availability: -
Code availability: -