| Expression pattern: |
UP |
| Associated gene: |
THBS2, Ago2 |
| Associated microRNA: |
miR-590-5p |
| Biological function: |
Promotes NSCLC cell proliferation and migration, inhibits apoptosis, and promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-590-5p to regulate THBS2 expression (ceRNA axis). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0020123 is upregulated in NSCLC tissues/cells and functions as an oncogenic circRNA. It sponges miR-590-5p to upregulate THBS2, thereby promoting proliferation and migration and inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.6825 |