circRNA basic information
circBase ID: hsa_circ_0044529
Name: hsa_circ_COL1A1
Synonym: -
Host Gene: COL1A1
Genomic location(hg19): chr17:48266102-48277308:-
Genomic location(hg38): chr17:50188741-50199947:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005595
MONDO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma / LSCC
Disease DO ID:
 2876
Disease MeSH ID:
 -
Disease NCIt ID:
 C4044
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

LSCC tissues; normal laryngeal mucosa tissues; normal control tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-4640-5p
Biological function: May be involved in the pathogenesis and tumorigenesis of LSCC by acting as a miRNA sponge for hsa-miR-4640-5p and participating in collagen synthesis-related processes.
Molecular mechanism: ceRNA mechanism; miRNA sponge mechanism; predicted circRNA-miRNA interaction involving hsa-miR-4640-5p
Biological pathway or process:

ceRNA regulation (other); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0044529 is up-regulated in LSCC tissues and was validated by qRT-PCR in both the test and independent validation cohorts. The study proposes that it may contribute to LSCC pathogenesis through a ceRNA-like miRNA sponge mechanism involving hsa-miR-4640-5p and collagen synthesis-related COL1A1-derived circRNA biology.
Confidence score:

0.5135
Other information
Title:

Circular RNA Expression Profile in Laryngeal Squamous Cell Carcinoma Revealed by Microarray.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Published: 2018
PubMed ID: 30282067
Study type:

combined clinical and bioinformatics study
Data availability: Table S1; Table S2; Table S3; Table S4; Table S5; Table S6; Fig. S1; Fig. S2; www.karger.com/10.1159/000494010/
Code availability: -