| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-7157-5p, hsa-miR-4769-3p, hsa-miR-6817-5p, hsa-miR-4310, hsa-miR-6882-3p |
| Biological function: |
hsa_circ_0061012 might be involved in the pathogenesis of psoriasis and might serve as a candidate biomarker for psoriasis. |
| Molecular mechanism: |
Predicted ceRNA mechanism through five miRNA response elements, with GO analysis of upregulated targets suggesting psoriasis-related processes including T cell selection, response to interleukin 4, and regulation of NF-kappaB import into nucleus. |
| Biological pathway or process: |
ceRNA regulation (promotes); immune regulation (other); inflammation (other); NF-kappaB (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0061012 might be a candidate biomarker for psoriasis. |
| Description: |
This study found that hsa_circ_0061012 is significantly up-regulated in psoriatic lesions and may serve as a candidate biomarker for psoriasis. Bioinformatic analyses suggested that hsa_circ_0061012 may function through a ceRNA-related mechanism involving five predicted miRNAs and psoriasis-related target processes such as T cell selection, response to interleukin 4, and regulation of NF-kappaB import into nucleus. |
| Confidence score: |
0.4032 |