circRNA basic information
circBase ID: hsa_circ_0001250
Name: hsa_circ_GRAMD4
Synonym: -
Host Gene: GRAMD4
Genomic location(hg19): chr22:47022647-47033857:+
Genomic location(hg38): chr22:46626750-46637960:+
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted miRNA sponge potential based on computational circRNA-miRNA network.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential biomarker for pancreatic cancer diagnosis (EV circRNA in plasma).
Description:

hsa_circ_0001250 is up-regulated in plasma EVs of PDAC patients and is included in the RT-qPCR validation set supporting sequencing results. Mechanistic/functional roles remain untested beyond predicted miRNA binding.
Confidence score:

0.5466
Other information
Title:

Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.

Journal: FEBS open bio
Published: 2019
PubMed ID: 31605569
Study type:

combined biological and clinical study
Data availability: -
Code availability: -