| Expression pattern: |
UP |
| Associated gene: |
TGF-alpha, EGFR |
| Associated microRNA: |
miR-152-3p |
| Biological function: |
Promotes prostate cancer cell migration and invasion; promotes prostate cancer progression; high expression is associated with poor prognosis. |
| Molecular mechanism: |
circANKS1B acts as a sponge for miR-152-3p and promotes PC progression by upregulating TGF-alpha expression; circANKS1B silencing suppresses TGF-alpha and EGFR expression, which is reversed by miR-152-3p deficiency. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes); invasion (promotes); EGFR (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Luciferase Reporter Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circANKS1B expression was associated with Gleason score, T stage, lymph node metastasis, and poor overall survival; circANKS1B may be a potential prognostic biomarker and therapeutic target for PC. |
| Description: |
circANKS1B is upregulated in prostate cancer tissues and cell lines, and high expression is associated with poor overall survival and adverse clinicopathological features. Functionally, circANKS1B promotes prostate cancer cell migration and invasion by sponging miR-152-3p and increasing TGF-alpha/EGFR expression, indicating potential value as a prognostic biomarker and therapeutic target. |
| Confidence score: |
0.6987 |