| Expression pattern: |
UP |
| Associated gene: |
ETS1, Ago2 |
| Associated microRNA: |
miR‐615‐5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration and invasion; inhibits apoptosis; promotes glutamine catabolism and tumor growth/tumor formation. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-615-5p to positively regulate ETS1 expression (ceRNA-like mechanism). |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); other pathway/process (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ‐PITX1 expression was associated with tumor size, TNM stage and lymphatic metastasis. |
| Description: |
circ-PITX1 is up-regulated in NSCLC and promotes malignant phenotypes (proliferation, migration/invasion), glutamine catabolism, and tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-615-5p to increase ETS1 expression, forming a circ-PITX1/miR-615-5p/ETS1 axis. |
| Confidence score: |
0.8299 |