| Expression pattern: |
DN |
| Associated gene: |
RASA1 |
| Associated microRNA: |
miR-145 |
| Biological function: |
circ-ITCH suppresses ovarian cancer progression by inhibiting cell proliferation, migration, invasion, motility, and in vivo tumorigenesis. |
| Molecular mechanism: |
circ-ITCH functions as a ceRNA sponge for miR-145, thereby increasing RASA1 expression and suppressing malignant progression of ovarian cancer cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low circ-ITCH expression correlates with worse prognosis in ovarian cancer patients; patients with low levels of circ-ITCH had shorter overall survival. |
| Description: |
circ-ITCH is down-regulated in ovarian cancer tissues and cells, and low expression is associated with poor prognosis. Functionally, circ-ITCH overexpression suppresses OC cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, circ-ITCH acts as a cytoplasmic ceRNA that sponges miR-145 to increase RASA1 expression, forming the circ-ITCH-miR-145-RASA1 tumor-suppressive axis. |
| Confidence score: |
0.817 |