| Expression pattern: |
UP |
| Associated gene: |
P-ERK, P-AKT, P-JNK, JNK, beta-catenin, GL11, BCL2, MMP2 |
| Associated microRNA: |
- |
| Biological function: |
circ-102004 promotes prostate cancer cell proliferation, migration, invasion and tumorigenicity, decreases apoptosis, and functions as an oncogenic circRNA in PCa. |
| Molecular mechanism: |
circ-102004 overexpression alters downstream gene expression and activates cancer-related signaling pathways including ERK, JNK, Hedgehog, Wnt/beta-catenin and AKT-related signaling, accompanied by upregulation of BCL2 and MMP2. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes); ERK (promotes); MAPK (promotes); Hedgehog (promotes); Wnt/beta-catenin (promotes); PI3K/AKT (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; RNA-seq; Bioinformatics Analysis; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circ-102004 may be used as a diagnostic biomarker and as a diagnostic or therapeutic target against PCa. |
| Description: |
circ-102004 is upregulated in prostate cancer tissues and acts as an oncogenic circRNA. Its overexpression promotes PCa cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, likely through activation of multiple cancer-related signaling pathways including ERK, JNK, Hedgehog and Wnt/beta-catenin. The study proposes circ-102004 as a potential diagnostic biomarker and therapeutic target for PCa. |
| Confidence score: |
0.73 |