| Expression pattern: |
UP |
| Associated gene: |
AGO1 |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
Circ_0075829 plays an oncogenic role in gastric cancer; silencing of circ_0075829 decreases gastric cancer cell viability, proliferation, migration, and invasion. |
| Molecular mechanism: |
circ_0075829 acts through a ceRNA-like mechanism involving miR-149-5p and regulation of AGO1 expression; H. pylori infection upregulates circ_0075829 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Survival Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
circ_0075829 expression was correlated with Helicobacter pylori infection, lymph node metastasis, TNM stage, Borrmann classification, and shorter overall survival; high expression may serve as a prognostic marker in gastric cancer. |
| Description: |
hsa_circ_0075829/circ_0075829 is up-regulated in gastric cancer tissues and cells, especially in H. pylori-positive contexts. It promotes gastric cancer cell proliferation, migration, and invasion through a miR-149-5p/AGO1 regulatory axis, and high circ_0075829 expression is associated with worse overall survival and adverse clinicopathological features. |
| Confidence score: |
0.7283 |