circRNA basic information
circBase ID: hsa_circ_0000896
Name: hsa_circ_FARSA
Synonym: -
Host Gene: FARSA
Genomic location(hg19): chr19:13039155-13039661:-
Genomic location(hg38): chr19:12928341-12928847:-
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

BxPC-3; COLO-357; PANC-1; SW1990
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted to have miRNA binding sites via TargetScan/miRanda (network-level prediction).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; Bioinformatics Analysis
Clinical significance:

Potential biomarker for pancreatic cancer diagnosis (EV circRNA in plasma).
Description:

hsa_circ_0000896 is up-regulated in plasma EVs from PDAC patients and was among circRNAs validated by RT-qPCR. It is detectable in pancreatic cancer cell lines and shows particularly high expression in SW1990; miRNA targets are computationally predicted only.
Confidence score:

0.62
Other information
Title:

Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.

Journal: FEBS open bio
Published: 2019
PubMed ID: 31605569
Study type:

combined biological and clinical study
Data availability: -
Code availability: -