| Expression pattern: |
UP |
| Associated gene: |
HAVCR2 |
| Associated microRNA: |
miR-490-5p |
| Biological function: |
promotes migration and invasion of osteosarcoma cells |
| Molecular mechanism: |
ceRNA mechanism: circPVT1 sequesters miR-490-5p to upregulate HAVCR2 |
| Biological pathway or process: |
migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circPVT1 is up-regulated in osteosarcoma cell lines and promotes migration and invasion. Mechanistically, it localizes mainly in the cytoplasm and acts as a ceRNA by sponging miR-490-5p, thereby upregulating HAVCR2 to drive these malignant phenotypes. |
| Confidence score: |
0.6683 |