| Expression pattern: |
UP |
| Associated gene: |
ABCC2, EGFR |
| Associated microRNA: |
hsa-miR-4757-3p, hsa-miR-490-3p, hsa-miR-3910, hsa-miR-584-5p, hsa-miR-1254, hsa-miR-593-5p |
| Biological function: |
Associated with osteosarcoma chemoresistance; potential oncogenic role; high expression related to poor prognosis; candidate target for reversing chemoresistance. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving hsa circ 0004674-miR-490-3p-ABCC2 and hsa circ 0004674-miR-1254-EGFR regulatory pathways. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; circRNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa circ 0004674 was overexpressed in OS tissues and chemoresistant OS tissues, and high expression was associated with shorter overall survival, suggesting poor prognosis and potential biomarker value. |
| Description: |
hsa circ 0004674 was the most upregulated circRNA in chemoresistant osteosarcoma cell lines and was also increased in OS tissues, especially chemoresistant tissues. Its high expression was associated with shorter overall survival, and predicted ceRNA axes involving miR-490-3p/ABCC2 and miR-1254/EGFR suggest a possible role in OS chemoresistance. |
| Confidence score: |
0.6238 |