| Expression pattern: |
DN |
| Associated gene: |
CBL, b-catenin, MYC, CCND1, SOX4 |
| Associated microRNA: |
miR-22-3p |
| Biological function: |
circ-ITCH acts as a tumor suppressor in PTC; its overexpression suppresses PTC cell proliferation and invasion, promotes apoptosis, and impairs tumor growth in vivo. |
| Molecular mechanism: |
circ-ITCH sponges miR-22-3p to upregulate CBL, which promotes b-catenin degradation and suppresses Wnt/b-catenin pathway activation. |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis; Western Blot; In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
circ-ITCH expression was associated with clinical stage and lymph node metastasis, and circ-ITCH was reported as an independent prognostic marker. |
| Description: |
circ-ITCH is downregulated in papillary thyroid cancer tissues and cell lines. Functionally, circ-ITCH suppresses PTC cell proliferation and invasion, promotes apoptosis, and inhibits xenograft tumor growth. Mechanistically, it sponges miR-22-3p to upregulate CBL, thereby suppressing beta-catenin/Wnt signaling. |
| Confidence score: |
0.7126 |