| Expression pattern: |
UN |
| Associated gene: |
FOXM1 |
| Associated microRNA: |
hsa-miR-149-5p |
| Biological function: |
promotes ovarian cancer cell viability/proliferation, migration and invasion; inhibits apoptosis; may contribute to drug resistance |
| Molecular mechanism: |
ceRNA mechanism: circPVT1 sponges miR-149-5p to relieve repression of FOXM1, increasing FOXM1 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); drug resistance (other); JAK/STAT (other) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In ovarian cancer cells, circPVT1 promotes cell viability/proliferation, migration and invasion and inhibits apoptosis. Mechanistically, circPVT1 acts as a ceRNA to sponge miR-149-5p, thereby increasing FOXM1 expression. |
| Confidence score: |
0.6376 |