| Expression pattern: |
DN |
| Associated gene: |
Wnt/beta-catenin pathway, Dvl2 |
| Associated microRNA: |
- |
| Biological function: |
tumor suppressor effect in HCC; inhibitory effect on HCC carcinogenesis |
| Molecular mechanism: |
Not explored in this study; discussed as inhibiting Wnt/beta-catenin pathway based on prior studies |
| Biological pathway or process: |
Wnt/beta-catenin (inhibits); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
high expression of circ-ITCH was associated with favorable survival of HCC; circ-ITCH could serve as susceptibility and prognostic biomarker for HCC patients |
| Description: |
circ-ITCH is down-regulated in HCC tumor tissues versus adjacent tissues and is associated with HCC susceptibility. Higher circ-ITCH expression predicts better overall survival, supporting a tumor-suppressive role in HCC; mechanistic details were not experimentally explored in this study (Wnt/beta-catenin inhibition is discussed mainly from prior literature). |
| Confidence score: |
0.6023 |