circRNA basic information
circBase ID: hsa_circ_0001551
Name: hsa_circ_RARS
Synonym: circRARS / circular RARS
Host Gene: RARS
Genomic location(hg19): chr5:167915606-167924353:+
Genomic location(hg38): chr5:168488601-168497348:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; paired adjacent normal tissues
Cell lines:

A549; SPC-A1; NCI-H1703; NCI-H1299; H1975; 16-HBE
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: LDHA
Associated microRNA: -
Biological function: Promotes NSCLC cell proliferation, invasion, migration, and aerobic glycolysis.
Molecular mechanism: circRARS binds LDHA, increases LDHA activity, and positively regulates LDHA expression at the transcriptional level, thereby enhancing glycolysis.
Biological pathway or process:

glycolysis (promotes); proliferation (promotes); invasion (promotes); migration (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Bioinformatics Analysis; Clinical Sample Validation; Survival Analysis
Clinical significance:

High circRARS expression is associated with smoking status, lymph node metastasis, higher tumor stage, and poor overall survival; may be a prognostic biomarker in NSCLC.
Description:

circRARS (hsa_circ_0001551), derived from RARS, is up-regulated in NSCLC/LUAD and associates with aggressive clinicopathologic features and poorer overall survival. Functionally, circRARS promotes proliferation, invasion, migration, and aerobic glycolysis, at least partly by binding LDHA and enhancing LDHA activity while upregulating LDHA expression at the transcriptional level.
Confidence score:

0.8369
Other information
Title:

Circular RNA, circular RARS, promotes aerobic glycolysis of non-small-cell lung cancer by binding with LDHA.

Journal: Thoracic cancer
Published: 2023
PubMed ID: 36628612
Study type:

combined biological and clinical study
Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -