| Expression pattern: |
UP |
| Associated gene: |
FUT3 |
| Associated microRNA: |
miR-1343-3p, miR-541-3p |
| Biological function: |
Involved in the formation/development of 5-Fu resistance in CRC cells; potential predictive biomarker/therapeutic target for 5-Fu resistance. |
| Molecular mechanism: |
Potential competitive endogenous RNA (ceRNA) mechanism via circRNA-miRNA-mRNA regulatory axes (e.g., circ_0002813-miR-1343-3p-FUT3). |
| Biological pathway or process: |
ceRNA regulation (other); drug resistance (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Bioinformatics Analysis |
| Clinical significance: |
May serve as a biomarker to predict the occurrence of 5-Fu resistance in CRC. |
| Description: |
hsa_circ_0002813 is up-regulated in 5-Fu-resistant CRC cell lines and is proposed to promote 5-Fu resistance via a ceRNA network, including an axis involving miRNAs (e.g., miR-1343-3p/miR-541-3p) and FUT3. It is suggested as a potential biomarker and therapeutic target for 5-Fu resistance in CRC. |
| Confidence score: |
0.2465 |