circRNA basic information
circBase ID: -
Name: hsa_circ_EPB41L2
Synonym: -
Host Gene: EPB41L2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum samples; adjacent non-tumor tissues; cancerous tissues
Cell lines:

BEAS-2B; A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Knockdown of hsa_circ-EPB41L2 inhibited A549 cell proliferation and promoted apoptosis; the authors suggested an oncogenetic role in lung adenocarcinoma.
Molecular mechanism: Not mechanistically defined; functional assays showed effects on proliferation and apoptosis.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; ROC Analysis; Survival Analysis
Clinical significance:

Low expression was associated with advanced TNM stage, lymph node metastasis, smoking, diagnostic AUC, and shorter overall survival and disease-free rates.
Description:

hsa_circ-EPB41L2 was down-regulated in lung adenocarcinoma serum and tissues. Lower expression was linked to advanced clinicopathological features and poorer survival, and silencing inhibited A549 proliferation and facilitated apoptosis, suggesting a pro-tumor role.
Confidence score:

0.6155
Other information
Title:

Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.

Journal: Clinical laboratory
Published: 2021
PubMed ID: 34383411
Study type:

combined biological and clinical study
Data availability: -
Code availability: -