| Expression pattern: |
UP |
| Associated gene: |
STMN1 |
| Associated microRNA: |
miR-145 |
| Biological function: |
Promotes proliferation, migration, and angiogenesis in nasopharyngeal carcinoma; increases VEGF in NPC cells and enhances VEGFR1/VEGFR2 expression and tube formation in HUVECs. |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-145, thereby relieving miR-145-mediated repression of STMN1 and promoting angiogenesis-related factors (VEGF/VEGFR1/VEGFR2). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); angiogenesis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; RNase R Treatment; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RNA Pull-Down; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-ZNF609 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes NPC cell proliferation and migration and HUVEC angiogenesis. Mechanistically, it sponges miR-145 (ceRNA), thereby increasing STMN1 expression and enhancing VEGF/VEGFR-related angiogenic activity. |
| Confidence score: |
0.7591 |