circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood (PB); bone marrow (BM)
Cell lines:

GF-D8; KG-1; NB4
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: let-7, miR-125
Biological function: -
Molecular mechanism: Correlation of circPVT1 overexpression with PVT1 copy-number gain in AML-amp; proposed miRNA sponge activity (let-7/miR-125 families).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

circPVT1 is significantly up-regulated in AML cases with 8q24/PVT1 amplification (AML-amp) and its expression correlates with PVT1 copy-number gain. The study mentions a proposed mechanism that circPVT1 may act as a miRNA sponge (let-7/miR-125 families), but functional effects in AML are not experimentally validated here.
Confidence score:

0.348
Other information
Title:

MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences.

Journal: Leukemia
Published: 2018
PubMed ID: 29467491
Study type:

combined biological and clinical study
Data availability: E-MTAB-5372; PRJNA386992; GenBank: MF084292-MF084375; MF125224-MF125264
Code availability: -