| Expression pattern: |
DN |
| Associated gene: |
TRMT10C, HSP90, AKT1 |
| Associated microRNA: |
- |
| Biological function: |
inhibits lung cancer growth by suppressing proliferation and migration and promoting apoptosis; inhibits glycolysis |
| Molecular mechanism: |
TRMT10C mediates m7G modification to increase circFAM126A stability; circFAM126A directly binds HSP90, promotes HSP90 ubiquitination and degradation, reduces AKT1/p-AKT signaling, downregulates HK2, and inhibits glycolysis |
| Biological pathway or process: |
PI3K/AKT (inhibits); glycolysis (inhibits); proliferation (inhibits); migration (inhibits); apoptosis (promotes); ubiquitination (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; MeRIP / MeRIP-seq; CLIP; RNA Pull-Down; RIP (RNA Immunoprecipitation); Co-IP; Transfection; CCK8; EdU Staining; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; IF (Immunofluorescence); Bioinformatics Analysis; ROC Analysis; H&E Staining |
| Clinical significance: |
circFAM126A expression correlates with lung cancer stage and tumour diameter and shows diagnostic value (ROC AUC: 0.7659). |
| Description: |
circFAM126A (hsa_circ_0005251) is down-regulated in lung cancer tissues and cell lines. Functionally, it suppresses lung cancer proliferation and migration and promotes apoptosis in vitro and inhibits tumor growth in a xenograft model. Mechanistically, TRMT10C-mediated m7G modification increases circFAM126A stability, and circFAM126A binds HSP90 to promote its ubiquitination, reducing AKT1 signaling and glycolysis. |
| Confidence score: |
0.8803 |