| Expression pattern: |
UP |
| Associated gene: |
PTK2, Ago2 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
promotes proliferation, invasion/migration (metastasis-related phenotypes) and glycolysis of HCC cells; supports tumor growth in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge: circC16orf62 sponges miR-138-5p to derepress PTK2, activating AKT/mTOR signaling |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); glycolysis (promotes); proliferation (promotes); invasion (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
M
|
| Validation methods: |
RT-qPCR; Microarray; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circC16orf62 expression is negatively associated to prognosis and is predictive of overall survival in HCC; associated with tumor diameter and lymph node metastasis |
| Description: |
CircC16orf62 is up-regulated in HCC and promotes malignant phenotypes (proliferation, invasion/migration, and aerobic glycolysis) and tumor growth. Mechanistically, it localizes mainly in the cytoplasm and acts as a ceRNA by sponging miR-138-5p to increase PTK2, thereby activating the AKT/mTOR pathway. High expression is associated with worse prognosis in HCC. |
| Confidence score: |
0.8834 |