| Expression pattern: |
UP |
| Associated gene: |
c-Fos, E2F2, Ago2 |
| Associated microRNA: |
miR-125b |
| Biological function: |
promotes NSCLC cell proliferation, migration, invasion and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
c-Fos induces circPVT1 upregulation; circPVT1 acts as a ceRNA by sponging miR-125b to modulate E2F2 signaling |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); metastasis (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; Luciferase Reporter Assay; Transfection; CCK8; Cell Cycle Assay; TUNEL; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circPVT1 may serve as a diagnostic biomarker for NSCLC; circPVT1 expression was positively correlated with distant metastasis and may have potential prognostic significance |
| Description: |
circPVT1 is up-regulated in NSCLC tissues, serum and cell lines, and shows diagnostic biomarker potential. Mechanistically, c-Fos activates circPVT1 expression, and circPVT1 promotes NSCLC proliferation, invasion, metastasis-related phenotypes and xenograft tumor growth by sponging miR-125b and activating the E2F2 pathway. |
| Confidence score: |
0.8769 |