| Expression pattern: |
UP |
| Associated gene: |
CXCR1, Ago2 |
| Associated microRNA: |
miR-1304 |
| Biological function: |
Circ_0067934 exerts a carcinogenic role in thyroid cancer; its knockdown induces apoptosis, inhibits proliferation, migration and invasion of TC cells, and suppresses tumor growth in vivo. |
| Molecular mechanism: |
circ_0067934 acts as a miR-1304 sponge and regulates CXCR1 expression through a circ_0067934/miR-1304/CXCR1 ceRNA axis. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Augmented circ_0067934 expression was connected with high AJCC grade, lymph node metastasis, and worse prognosis in TC patients. |
| Description: |
circ_0067934 is up-regulated in thyroid cancer tissues and cells and is associated with advanced AJCC grade, lymph node metastasis, and poor prognosis. Functionally, circ_0067934 promotes TC cell proliferation, migration and invasion and suppresses apoptosis, while its knockdown inhibits xenograft tumor growth. Mechanistically, it acts as a sponge for miR-1304 to increase CXCR1 expression through a circ_0067934/miR-1304/CXCR1 axis. |
| Confidence score: |
0.817 |