| Expression pattern: |
UP |
| Associated gene: |
BDNF |
| Associated microRNA: |
miR-646 |
| Biological function: |
Enhances osteosarcoma progression and DOX resistance by promoting proliferation, migration and invasion and inhibiting apoptosis; circ_0000006 knockdown increases DOX sensitivity and suppresses tumor growth. |
| Molecular mechanism: |
ceRNA mechanism: circ_0000006 sponges miR-646, relieving miR-646-mediated repression of BDNF (miR-646 binds BDNF 3'UTR). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0000006 is up-regulated in osteosarcoma tissues/cells and is reduced by doxorubicin treatment. It promotes malignant phenotypes and DOX resistance by sponging miR-646 to increase BDNF; circ_0000006 knockdown enhances DOX-mediated anti-tumor effects and suppresses xenograft tumor growth. |
| Confidence score: |
0.7183 |