| Expression pattern: |
UP |
| Associated gene: |
ERG |
| Associated microRNA: |
miR-1271 |
| Biological function: |
CircRNA_103993 promotes proliferation and inhibits apoptosis of NSCLC cells; knockdown of CircRNA_103993 inhibits proliferation and promotes apoptosis. |
| Molecular mechanism: |
CircRNA_103993 acts as a ceRNA/sponges miR-1271 to regulate ERG signaling in NSCLC cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
CircRNA_103993 may be a potential molecular marker in NSCLC and a target for lung cancer treatment. |
| Description: |
CircRNA_103993 is up-regulated in human NSCLC cell lines compared with bronchial epithelial control cells. Functionally, it promotes NSCLC cell proliferation and suppresses apoptosis. Mechanistically, CircRNA_103993 acts as a ceRNA/sponges miR-1271 to regulate ERG signaling, suggesting potential value as a molecular marker and therapeutic target. |
| Confidence score: |
0.5554 |