| Expression pattern: |
UP |
| Associated gene: |
matrix metalloproteinases family members (MMPs), MMP2, MMP17, AGO2 |
| Associated microRNA: |
miR-1299, miR-7 |
| Biological function: |
ciRS-7 promotes TNBC cell migration, invasion, and liver and lung metastasis; knockdown of ciRS-7 suppresses these metastatic phenotypes without an apparent effect on proliferation. |
| Molecular mechanism: |
ciRS-7 acts as a ceRNA/sponge of miR-1299 in TNBC cells, releasing miR-1299-mediated repression and enhancing MMP2/MMP17 and MMP family expression to maintain migration and invasion. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
ciRS-7 is highly expressed in TNBC and its expression is associated with tumor infiltration, lymphnode metastasis, pathological grade, clinical stage, and poor clinicopathological characteristics. |
| Description: |
ciRS-7 is up-regulated in TNBC tissues and cells and is associated with aggressive clinicopathological features. It promotes TNBC migration, invasion, and metastasis by acting as a ceRNA for miR-1299, thereby enhancing MMP2/MMP17 and MMP family expression. |
| Confidence score: |
0.8278 |