| Expression pattern: |
DS |
| Associated gene: |
TPX2, GATA3 |
| Associated microRNA: |
hsa-miR-338-3p |
| Biological function: |
May function as a ceRNA in bladder cancer by capturing hsa-miR-338-3p and involving TPX2 and GATA3, but its exact role requires further determination due to inconsistent qRT-PCR validation. |
| Molecular mechanism: |
ceRNA mechanism; hsa_circ_0028173 may capture hsa-miR-338-3p to regulate TPX2 and GATA3. |
| Biological pathway or process: |
ceRNA regulation (other); lipid metabolism (other); p53 signaling (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Potential biomarker or therapeutic target for bladder cancer diagnosis and treatment, but the exact role needs further determination. |
| Description: |
hsa_circ_0028173 was identified as dysregulated in bladder cancer, with integrated analysis suggesting upregulation but qRT-PCR showing an inconsistent trend. The study proposes a possible hsa_circ_0028173/hsa-miR-338-3p/TPX2/GATA3 ceRNA axis, but states that its exact role in BC requires further study. |
| Confidence score: |
0.4032 |