| Expression pattern: |
UP |
| Associated gene: |
SOD2 |
| Associated microRNA: |
miR-212-5p |
| Biological function: |
promotes ovarian cancer cell growth, migration and invasion, and promotes glycolysis; its repression (by propofol or silencing) restrains these phenotypes |
| Molecular mechanism: |
circ-ZFR acts as a miRNA sponge for miR-212-5p, thereby regulating SOD2 and affecting glycolysis and malignant behaviors; propofol reduces circ-ZFR expression |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In A2780 ovarian cancer cells, circ-ZFR is increased and promotes malignant phenotypes and aerobic glycolysis. Propofol lowers circ-ZFR, relieving its sponge effect on miR-212-5p and thereby reducing SOD2, which restrains glycolysis and cell progression. |
| Confidence score: |
0.6253 |