| Expression pattern: |
UP |
| Associated gene: |
IGF2BP3 |
| Associated microRNA: |
miR-654 |
| Biological function: |
Promotes glioma cell proliferation, invasion, aggressive behaviors, tumor propagation and tumor growth in vivo. |
| Molecular mechanism: |
circHIPK3 acts through a ceRNA-like mechanism by interacting with miR-654 to promote IGF2BP3 expression in glioma cells. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; EdU Staining; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
Elevated circHIPK3 level was linked to poor prognosis and may serve as a potential therapeutic target for glioma. |
| Description: |
circHIPK3 is up-regulated in human glioma tissues and cell lines, and high expression predicts poor prognosis. Functionally, circHIPK3 promotes glioma proliferation, invasion and xenograft tumor growth by regulating the miR-654/IGF2BP3 axis, suggesting an oncogenic role and potential therapeutic relevance. |
| Confidence score: |
0.7113 |