| Expression pattern: |
UP |
| Associated gene: |
NRAS |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
promotes proliferation, migration, and invasion of HCC cells |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-145-5p to increase NRAS expression (ceRNA mechanism). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay |
| Clinical significance: |
High hsa_circ_0001955 expression was significantly positively correlated with large tumor size and advanced TNM stage. |
| Description: |
hsa_circ_0001955 is up-regulated in HCC tissues and cell lines and promotes HCC cell proliferation, migration, and invasion. Mechanistically, it acts in the cytoplasm as a sponge of miR-145-5p, thereby increasing NRAS expression via a ceRNA axis. |
| Confidence score: |
0.6777 |