| Expression pattern: |
DN |
| Associated gene: |
cyclin D1, cyclin B1, E-cadherin, N-cadherin, Caspase-3, Cleaved Caspase-3, Bax, Bcl-2 |
| Associated microRNA: |
- |
| Biological function: |
CircRNA_104916 functions as a tumor suppressor in colorectal cancer by inhibiting cell proliferation, migration, invasion and EMT, while promoting apoptosis and G2/M phase arrest. |
| Molecular mechanism: |
CircRNA_104916 overexpression activates apoptosis-related proteins and cell-cycle checkpoint protein changes, and inhibits EMT marker changes, resulting in suppressed proliferation, migration and invasion. |
| Biological pathway or process: |
apoptosis (promotes); cell cycle (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Cohort Study; Survival Analysis |
| Clinical significance: |
CircRNA_104916 is a potential biomarker and therapeutic target for colorectal cancer; higher expression is associated with better disease-free survival and circRNA_104916 independently predicts prognosis. |
| Description: |
CircRNA_104916 is downregulated in colorectal cancer tissues and cell lines, and higher expression is associated with better disease-free survival. Functional experiments show that circRNA_104916 overexpression suppresses CRC proliferation, migration, invasion and EMT, while promoting apoptosis and G2/M phase arrest. The study supports circRNA_104916 as a potential tumor suppressor, biomarker and therapeutic target in CRC. |
| Confidence score: |
0.6589 |