| Expression pattern: |
UP |
| Associated gene: |
NOTCH1 |
| Associated microRNA: |
miR-665 |
| Biological function: |
promotes radioresistance, proliferation, migration and invasion; inhibits apoptosis; circ_0005615 knockdown enhances radiosensitivity in vitro and in vivo |
| Molecular mechanism: |
circ_0005615 acts as a miRNA sponge (ceRNA) for miR-665, thereby increasing NOTCH1 expression and promoting radioresistance |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); radioresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; Colony Formation Assay; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circ_0005615 level was higher in the high-radiosensitive (recurrent after radiation treatment) group than in the less-radiosensitive group; suggested as a potential biomarker for CRC radiotherapy |
| Description: |
circ_0005615 is up-regulated in colorectal cancer and mainly localized in the cytoplasm. It promotes radioresistance by sponging miR-665 to upregulate NOTCH1, thereby supporting CRC cell survival/proliferation and migration/invasion while reducing apoptosis; its knockdown increases radiosensitivity in vitro and in a LOVO xenograft model. |
| Confidence score: |
0.6837 |