| Expression pattern: |
UP |
| Associated gene: |
CBX8 |
| Associated microRNA: |
miR-518d-5p/519-5p family, miR-519a-5p, miR-519c-5p, miR-518e-5p |
| Biological function: |
Promotes cervical cancer cell proliferation, cell cycle progression, migration and invasion; knockdown inhibits proliferation, migration and invasion and increases G0/G1 arrest. |
| Molecular mechanism: |
circRNA8924 functions as a competitive endogenous RNA by sponging the miR-518d-5p/519-5p family, thereby relieving miRNA-mediated repression of CBX8 and upregulating CBX8 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High circRNA8924 expression is associated with tumor size, FIGO staging and myometrial invasion, and may serve as a biomarker for cervical cancer diagnosis and disease progression. |
| Description: |
circRNA8924 is up-regulated in cervical cancer tissues and correlates with more aggressive clinicopathological features. It promotes cervical cancer cell proliferation, cell cycle progression, migration and invasion by acting as a ceRNA for the miR-518d-5p/519-5p family and increasing CBX8 expression. The study proposes circRNA8924 as a potential diagnostic/progression biomarker and therapeutic target in cervical cancer. |
| Confidence score: |
0.7404 |