circRNA basic information
circBase ID: -
Name: hsa_circ_FCHO2
Synonym: circFCHO2
Host Gene: FCHO2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
9119
Disease MeSH ID:
D015470
Disease NCIt ID:
C3171
Disease ICD11 ID:
-
Disease OMIM ID:
601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow; blood

Cell lines:

-

In vivo animal model:

-

circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: High circFCHO2 expression was associated with better outcomes and independently longer OS and EFS in multivariable analyses, but no distinct gene expression pattern was identified.
Molecular mechanism: No distinct gene expression pattern and no repeat miR-sequestering regions were identified; circFCHO2 expression moderately correlated with linear FCHO2 expression.
Biological pathway or process:

not specified

Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis

Clinical significance:

High circFCHO2 expression was independently associated with better clinical outcome, including longer OS and EFS.

Description:

circFCHO2 is a prognostic circRNA in CN-AML. High expression is associated with better outcomes and remains independently associated with longer OS and EFS in multivariable analyses, although no distinct gene expression pattern was found.

Confidence score:

0.5534

Other information
Title:

Clinical and functional significance of circular RNAs in cytogenetically normal AML.

Journal: Blood advances
Published: 2020
PubMed ID: 31945158
Study type:

combined biological and clinical study

Data availability: -
Code availability: -