| Expression pattern: |
UP |
| Associated gene: |
LARP1 |
| Associated microRNA: |
miR-503 |
| Biological function: |
promotes lung cancer cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
circ-BANP acts as a miR-503 sponge to relieve miR-503-mediated inhibition of LARP1, thereby increasing LARP1 expression in lung cancer |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
higher circ-BANP expression was associated with lower survival rate and may be a potential prognostic biomarker in lung cancer |
| Description: |
circ-BANP is up-regulated in lung cancer tissues and cell lines, and high expression predicts poor survival. Functionally, circ-BANP promotes proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts through a circ-BANP/miR-503/LARP1 ceRNA axis to increase LARP1 expression and drive lung cancer progression. |
| Confidence score: |
0.7113 |