| Expression pattern: |
UP |
| Associated gene: |
IGF-1 / insulin-like growth factor (IGF)-1 |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
circ_0014130 promotes NSCLC cell proliferation and inhibits apoptosis; silencing circ_0014130 inhibits proliferation and promotes apoptosis. |
| Molecular mechanism: |
circ_0014130 interacts with miR-142-5p and regulates IGF-1 expression through miR-142-5p, consistent with a ceRNA-like mechanism. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
This might provide new strategies for future diagnosis and treatment of NSCLC. |
| Description: |
circ_0014130 is up-regulated in NSCLC tissues and cells. Functionally, circ_0014130 promotes NSCLC cell proliferation and suppresses apoptosis, while silencing circ_0014130 reverses these phenotypes. Mechanistically, circ_0014130 acts through the miR-142-5p/IGF-1 axis, with circ_0014130 knockdown increasing miR-142-5p and reducing IGF-1 expression. |
| Confidence score: |
0.6996 |