| Expression pattern: |
DN |
| Associated gene: |
PTEN, PI3K, AKT, Ago2 |
| Associated microRNA: |
miR-494-3p |
| Biological function: |
inhibits proliferation, migration, and invasion of NSCLC cells |
| Molecular mechanism: |
ceRNA mechanism: circ_0000317 sponges miR-494-3p to increase PTEN expression and suppress PI3K/AKT pathway activation |
| Biological pathway or process: |
PI3K/AKT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; Transwell Assay; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Circ_0000317 expression in NSCLC patients was associated with TNM stage and lymphatic metastasis. |
| Description: |
hsa_circ_0000317 (circ_0000317) is down-regulated in NSCLC tissues and cell lines and acts as a tumor suppressor by inhibiting NSCLC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA that sponges miR-494-3p, thereby up-regulating PTEN and inhibiting PI3K/AKT pathway activation. |
| Confidence score: |
0.7589 |