| Expression pattern: |
UP |
| Associated gene: |
CAMK1D |
| Associated microRNA: |
miR-219a-5p |
| Biological function: |
CircPRKCI promotes LUAD cell proliferation and migration, facilitates cell cycle progression, is associated with lymph node metastasis, and high expression is linked to poor prognosis. |
| Molecular mechanism: |
CircPRKCI binds to miR-219a-5p and probably modulates CAMK1D expression via the miR-219a-5p/CAMK1D axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); cell cycle (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Transwell Assay; Cell Cycle Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
High circPRKCI expression is associated with larger tumor diameter, higher tumor stage, lymph node metastasis, low survival rate, and poor prognosis in LUAD patients. |
| Description: |
CircPRKCI is up-regulated in LUAD tissues and cell lines and its high expression is associated with unfavorable prognosis. Functionally, circPRKCI promotes LUAD cell proliferation, migration, and cell cycle progression, at least partly through binding miR-219a-5p and regulating CAMK1D. |
| Confidence score: |
0.7113 |