| Expression pattern: |
UP |
| Associated gene: |
FKBP8, RNF25 |
| Associated microRNA: |
- |
| Biological function: |
promotes migration and invasion; promotes liver metastasis; shortens overall survival (mouse model) |
| Molecular mechanism: |
circSATB1 acts as a scaffold to enhance RNF25-FKBP8 interaction, promoting RNF25-mediated K48-linked ubiquitination and proteasomal degradation of FKBP8, thereby releasing inhibition of mTOR signaling |
| Biological pathway or process: |
mTOR signaling (promotes); metastasis (promotes); migration (promotes); invasion (promotes); EMT (promotes); ubiquitination (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); IF (Immunofluorescence); Co-IP; Transfection; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Western Blot; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
High circSATB1 expression is associated with liver metastasis-related clinicopathological features and predicts unfavorable prognosis; plasma exosomal circSATB1 shows diagnostic value for CRLM (AUC 0.718). |
| Description: |
circSATB1 (hsa_circ_0064557) is up-regulated in CRC, especially in cases with liver metastasis, and high expression predicts worse OS/PFS. It promotes CRC migration/invasion and liver metastasis by scaffolding RNF25 and FKBP8 to enhance RNF25-mediated K48 ubiquitination and proteasomal degradation of FKBP8, thereby activating mTOR signaling. circSATB1 is also detectable in plasma exosomes and has diagnostic value for CRLM. |
| Confidence score: |
0.887 |